In antibody drug conjugates (ADCs), two types of linkers are typically used: cleavable linkers and non-cleavable linkers.

Cleavable linkers release the cytotoxic payload near the desired location within the target cell, leading to the killing of the tumor and potentially neighboring cells. These linkers are designed to be degraded by specific enzymes or conditions within the cell.

Non-cleavable linkers, on the other hand, release the potent payload at the desired site within the cell, minimizing off-site toxicity. With non-cleavable linkers, the payload is delivered through endocytosis or other internalization mechanisms, and the linker remains attached to the antibody or payload during this process.

Both types of linkers have their advantages and disadvantages, and the choice of linker depends on the specific therapeutic goals and requirements of the ADC.

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